Somatropin

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Somatropin HGH Online Information
Somatropin® [somatropin (rDNA origin) for injection] is a human growth hormone produced by recombinant DNA technology. Somatropin® has 191 amino acid residues and a molecular weight of 22125 daltons. Its amino acid sequence and structure are identical to the predominant form of human pituitary growth hormone.

How Somatropin is made for bio-identical HGH therapy
Somatropin® is produced by a mammalian cell line mouse C127 that has been modified by the addition of the human growth hormone. Somatropin®, with the correct three-dimensional configuration, is excreted directly through the cell membrane in the cell culture medium for collection and purification. Somatropin® human growth hormone is a highly purified preparation and the biological potency is determined by measuring the increased body weight induced by pituitary sectomized testing.

Somatropin® is a sterile, non-pyrogenic, white, lyophilized powder intended for subcutaneous or intramuscular injection after reconstitution with bacteriostatic water for injection, USP (0.9% benzyl alcohol). The reconstituted solution has a pH of 6.5 to 8.5.

In what doses can I buy Somatropin Growth Hormone
Somatropin® is available in 5 mg and 8.8 mg vials. The quantitative composition of HGH per 5 mg per ampoule is 5 mg somatropin, 34.2 mg sucrose and 1.16 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.

 The pH is adjusted with sodium hydroxide or O-phosphoric acid.

The diluent is bacteriostatic water for injection, USP containing 0.9% benzyl alcohol added as an antimicrobial preservative.

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Buy Somatropin HGH pens online
Somatropin® is available in Somatropin Pen®, One. Click, HGH Injection Devices2 and Easypod somatropin delivery system and reconstitution device. The quantitative composition of HGH per vial bottle available in the Somatropin pen devices you can buy is as follows:

8.8 mg vial included in the click.easy® device: Each vial contains 8.8 mg somatropin, 60.2 mg sucrose and 2.05 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.
4 mg vial provided in the click.easy® device: Each vial contains 4 mg somatropin, 27.3 mg sucrose and 0.9 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.
The diluent in the click.easy® unit contains 0.3% (w / v) metacresol in sterile water for injection added as an antimicrobial preservative. The reconstituted solution has a pH of 6.5 to 8.5.
Facts about growth hormone for Somatropin
Somatropin® HGH is one of the leading bioidentical drugs used in HRT for the treatment of human growth hormone deficiency in adults (AGHD) and in children. Manufactured by the pharmaceutical company Somatropin EMD Somatropin, Somatropin Somatropin has provided health and anti-aging benefits for individuals dealing with the effects of AGHD – growth hormone deficiency in adults. Somatropin growth hormone has the following medical indications in adults: To correct a deficiency caused by a pituitary tumor, cancer, radiation therapy, trauma, hypothalamus or other disease. To replenish the missing supply in connection with age-related decline.Before prescribing Somatropin Human Growth Hormone, a hormone replacement specialist will examine your blood tests to make sure a low HGH condition exists. The information gathered from analyzes of hormone laboratory tests also provides the medical basis for determining your dosage and use of somatropin treatment. Each patient also undergoes a medical physical examination by a licensed physician, and a complete medical history helps your endocrinologist design an individualized HGH Replacement Therapy program. There are a number of delivery methods for self-administration when you want to buy human growth hormone Somatropin for therapy. In addition to the traditional needle and syringe method sold online, you can take your Somatropin shots with a handy pen unit.and a complete medical history will help your endocrinologist design an individualized HGH Replacement Therapy program. There are a number of delivery methods for self-administration when you want to buy human growth hormone Somatropin for therapy. In addition to the traditional needle and syringe method sold online, you can take your Somatropin shots with a handy pen unit. and a complete medical history will help your endocrinologist design an individualized HGH Replacement Therapy program. There are a number of delivery methods for self-administration when you want to buy human growth hormone Somatropin for therapy. In addition to the traditional needle and syringe method sold online, you can take your Somatropin shots with a handy pen unit.

Somatropin HGH Pen devices for sale
Somatropin Easy, Click® – this is a HGH pen device that automatically inserts a needle and administers a current dose of HGH into the body. It is used with Somatropin 8.8 mg click. Simple cartridges mixed in Somatropin Pen disposable reconstitution device before use. The preset dosing function eliminates the daily step of hitting the correct dose.
Somatropin HGH Injection Devices 2® – a needle-free HGH delivery system available for adults who do not want to use a needle. The drug is spread through the skin with a spring mechanism. It has a digital display and is used with Somatropin 5 mg and 8.8 mg vials that must first be reconstituted with bacteriostatic aqueous solution.
Somatropin One.Click® – an automatic injector pen unit containing replaceable cartridges and a steering wheel dosing system. The pen unit is held against the skin while the yellow button is pressed. Hold the device in place for at least 5 seconds to ensure that all Somatropin medicine is injected.
Somatropin Easypod® – another needle-free HGH delivery device available for adults who do not want to use a needle. The drug is spread through the skin with a spring mechanism. It has a digital display and is used with Somatropin 5 mg and 8.8 mg vials which must first be reconstituted with bacteriostatic solution.

Somatropin Summary and Prescription Facts
Somatropin is a human growth hormone produced by recombinant DNA technology: it has 191 amino acid residues, a molecular weight of 22 KD and an identical amino acid sequence and structure, to the dominant form of human pituitary growth hormone. Somatropin is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the human growth hormone.

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 The reconstituted solution has a pH of 6.5 to 8.5. It is supplied in 1 vial x 8 mg 24 IU (automatically prepared) and contains 8.8 mg somatropin, 60.2 mg sucrose and 2.05 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.

Somatropin Somatropin Bio-chemical action

Somatropin Somatropin binds to dimeric growth hormone receptors located in the cell membranes of target tissue cells resulting in intracellular signal transduction and pharmacodynamic effects: skeletal, cell and organ growth, protein synthesis (increased uptake of amino acids and nitrogen retention), carbohydrate retention metabolism, mineral metabolism and sodium in the body), connective tissue and bone metabolism (increased synthesis of chondroitin sulfate, collagen and increased excretion of hydroxyproline).

Indications

Somatropin is indicated for the treatment of pediatric patients with growth defects due to insufficient secretion of endogenous growth hormone.

In adults, Somatropin is medically indicated for HGH hormone replacement therapy in either:

Adult onset GHD: growth hormone deficiency alone or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy or trauma
Childhood Onset GHD caused by congenital, genetic, acquired or idiopathic causes.
Patients with closed epiphyses should be evaluated before continuing somatropin treatment.

Somatropin Safety Information

Before prescribing Somatropin, your doctor should take care of the following:

Male patients with one or more of the known risk factors are at greater risk;
Neoplasms: patients with pre-existing tumors should be monitored for progression or recurrence, as well as for potential malignant transformation of skin lesions, ie. increased growth of existing nevi. Childhood cancer survivors if treated with somatropin have an increased risk of a second neoplasm, especially meningioma in those treated with radiation to the head for their first neoplasm;
Treatment with somatropin may reduce insulin sensitivity, especially at high doses in susceptible patients (obese, with Turner syndrome or with a family history of diabetes mellitus). Glucose levels should therefore be monitored in all patients.especially in diabetic patients – dosing of concomitant antihyperglycaemic drugs (such as insulin, oral agents) may require adjustment.
Intracranial hypertension with papillae, vision changes, headache, nausea and / or vomiting have been reported in a few cases; such symptoms usually occur 8 weeks after starting somatropin treatment and can be reversed by reducing the dose or stopping treatment; those with Turner syndrome and Prader-Willi syndrome may be at higher risk of developing IH;
Fluid retention – often in adults, such as edema, arthralgia or carpal tunnel syndrome. Dose reduction is required in such cases;
Other hormone therapies should be closely monitored due to an increased risk of hypopituitarism;
Hypothyroidism may become apparent or worsen in patients with GHD;
Patients with Turner syndrome are at risk for autoimmune thyroid disease and primary hypothyroidism
Children with a painful or hip / knee pain should be evaluated for sliding main femoral epiphysis
Existing scoliosis may worsen in rapidly growing pediatric patients

Those with Turner syndrome are at higher risk for ear and hearing problems, eg otitis media and also cardiovascular diseases such as stroke, aortic aneurysm / dissection or high blood pressure;
Rotation of the injection site is necessary to avoid tissue atrophy;
Local or systemic allergic reactions are possible;
Serum levels of inorganic phosphorus, alkaline phosphatase, parathyroid hormone (PTH) and IGF-I may increase;
Pancreatitis should be considered in patients with persistent severe abdominal pain.
Physicians should consider the total daily metabolic load of benzyl alcohol before prescribing  or other medicines containing BA.

Once Somatropin HGH treatment has started, the risks and side effects of continued HGH should be evaluated if the patient has any of the following: scoliosis, diabetes, cancer, hormone deficiency, trauma, complaints of hip or knee pain, lameness or difficulty breathing . Tests for blood glucose and funduscopic examination (an eye test for intracranial hypertension) must be performed before and regularly after treatment.

HGH Side effects that may occur after treatment with  include edema (water recurrence), muscle pain, headache, numbness, swelling, loss of fat tissue under the skin, lipoatrophy, irritation or rash at the injection sites. Rotating injection sites for your Somatropin shot can help reduce irritation and adjusting the dose can help relieve most symptoms of HGH overuse.

HGH Side Effects

Medical HGH side effects of overdose include: extreme edema or water retention, bloating, pain, numbness, tingling in the feet, redness or swelling at the injection site, hypothyroidism, hypoglycaemia, muscle and joint pain, cramps or cramps and worsening of psoriasis symptoms that may have been present. before hormone therapy began.

In adults, carpal tunnel syndrome is a very common symptom of HGH overdose, arthralgia, myalgia, paresthesia and hypesthesia have also been reported.